denosumab injection how to give

The area will first be sterilized with rubbing alcohol. Find information on cost and zoledronic acid, how generic and brand-name prices compare, what financial assistance is available, and more. This can make it easier for you, as well as the healthcare team member giving the shot. XGEVA can significantly lower the calcium levels Always follow the dosage that your doctor prescribes for you. Denosumab (Prolia) is a monoclonal antibody given as a twice-yearly injection. In multiple myeloma patients receiving XGEVA, the most common side effects were diarrhea, nausea, low red blood cells, low blood platelets and calcium levels, back pain, swelling of the lower legs or hands, upper respiratory tract infection, rash, and headache. If your hypercalcemia is caused by high levels of vitamin D, short-term use of steroid pills such as prednisone are usually helpful. Talk to your doctor in advance about setting up an appointment for once every 4 weeks. A once-a-year injection is also far easier to schedule and stick to compared to having to remember a daily pill. To learn how to talk to your patient and calm them down before giving an injection, read more from our Nurse co-author! Denosumab injection comes as a solution (liquid) to be injected subcutaneously (under the skin) in your upper arm, upper thigh, or stomach area. There are also some rare side effects, including jaw damage, loose teeth, and fractures in the thigh. Here's who Wall Street thinks will win the midterm elections A sharp decline in Americans' disposable income this year bodes ill for Democrats, according to Goldman Sachs. If you are a Mayo Clinic patient, this could Sign Up The drugs typical dosage is the same regardless of why Prolia is prescribed. Finally, make sure to dispose of the needle properly in a special needle receptacle. in your blood and some deaths have been reported. Prolia is an injection that can be self-administered once every six months for the treatment of osteoporosis. Actonel is a prescription drug used to treat osteoporosis. Was this page helpful? hko6c-,:t:k8J"VDGn3OyodiF0)I`i=V@9s(A"(4,j@bGpf#Q QH4{89zU& It is given under the skin and does not involve an infusion through the vein. It helps prevent scars and skin damage. Prolia is safe to use for as long as your doctor recommends. The Royal Australian College of General Practitioners acknowledges Aboriginal and Torres Strait Islander peoples as the Traditional Custodians of the land and sea in which we live and work, we recognise their continuing connection to land, sea and culture and pay our respects to Elders past, present and future. You can practice by injecting water into an orange. To help make sure that you dont miss a dose, try using a medication reminder. This drug is often used to treat people with cancer-caused hypercalcemia who don't respond well to bisphosphonates. Important Safety Information Administer Prolia via subcutaneous injection. Prolia (Denosumab) Recommendation 19 The pictures and the rationale for action were particularly helpful. Continue taking these supplements at the dose prescribed by your doctor to help prevent low calcium levels in the blood. Learn more about ONJ here. Applies to denosumab: subcutaneous solution. In clinical studies, osteonecrosis of the jaw (ONJ) was reported in some people taking XGEVA, which can be serious. blood calcium must be treated before you receive XGEVA. @Z=` Call your doctor for medical advice about side effects. information submitted for this request. The following information describes the dosage, including the frequency of Prolia injections, that is commonly used or recommended. Hypocalcaemia following denosumab administration is a significant risk in patients with severe renal impairment (chronic kidney disease stage 4 or 5) or in patients receiving dialysis. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. They usually administer this drug by intravenous injection into the veins every 3 to 4 weeks. How to Inject Yourself: 13 Ways to Stay Safe and Sterile, How to Make Shots Pain-Free: Effective Distraction and Relaxation Strategies for Adults & Children. This can include setting an alarm or timer on your phone or downloading a reminder app. And, older people are more likely to be affected by osteoporosis, which Prolia is used to treat. Your doctor will determine the best dosage schedule to fit your needs. Recommendation 18 It is used to treat secondary bone cancer. It prevents bone-dissolving osteoclast cells from forming. Call your doctor right away if you believe youve received too much Prolia. XGEVA can significantly lower Press gently on the injection site with the 2 x 2 gauze. How often you receive Prolia injections isnt affected by how long youve used the medication. The medication is designed to be injected into a muscle and not into the bloodstream, so if you see any red color when you pull back you will need to remove the needle and dispose of it. With the vial upside-down and the tip of the needle in the medicine, draw the plunger back again to the proper dose (or a little past if there might be air bubbles). The amount of medication in a cc is the same as in an mL. XGEVA. HOW TO USE: Read the Medication Guide provided by your pharmacist before you start using denosumab and before each injection. After the shot, this area will be sterilized again and covered with some cotton and a bandage. By signing up you are agreeing to receive emails according to our privacy policy. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. To learn how to talk to your patient and calm them down before giving an injection, read more from our Nurse co-author! Enjoy! unlocking this expert answer. {{configCtrl2.info.metaDescription}} Sign up today to receive the latest news and updates from UpToDate. Find out what the recommended dosages are, how to take the drug, and more. Do not take XGEVA if you are allergic to denosumab or any The content of this article is not intended to be a substitute for professional medical advice, examination, diagnosis, or treatment. There are pamphlets and videos that can teach you how to give yourself an injection under the skin. Nonprofit organization focused on promoting the use of vaccines by distributing information about vaccines and the diseases they prevent. As with any drug, never change your dosage of Prolia without your doctors approval. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. You only need to do this for dorsogluteal muscles since youre close to the gluteal artery. Prolia (denosumab) is a brand-name prescription drug that's approved to treat osteoporosis and reduce bone loss. Do not take XGEVA if you have low blood calcium Denosumab is also used to treat giant cell tumor of the bone that cannot be removed by surgery. Your doctor will correct calcium levels if they are too low. Before you give a Prolia injection, make sure you are trained by a health professional to master the technique. Ankylosing Spondylitis Pain: Fact or Fiction, https://www.fda.gov/files/drugs/published/Biological-Product-Definitions.pdf, https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/125320s207lbl.pdf, 8-week mindfulness program as effective as antidepressant for treating anxiety. Prolia is given as a subcutaneous injection by your doctor, pharmacist, or another healthcare professional, in most cases. Your carer can also use the outer area of your upper arm. Serious bone problems are defined as broken bones (fractures), the need for surgery to bones, the need for radiation treatments to the bone, and spinal cord compression. o{$!7,f e:7bbj~- Xmxx(.jE4w_~y-gD(jURuy0Z|OYn00_i/Y=j/Filter/FlateDecode/ID[<30A52E187DB7394E9E664D34C4FC2508>]/Index[410 45]/Info 409 0 R/Length 94/Prev 38752/Root 411 0 R/Size 455/Type/XRef/W[1 2 1]>>stream The two-year Denosumab Fracture Intervention Randomised Placebo Controlled Trial (DIRECT)7 measured fracture incidence with denosumab treatment versus placebo in Japanese men and women older than 50 years of age with 14 prevalent fractures and mean T-scores of 2.8 at the lumbar spine and 2.0 at the hip. Your doctor or pharmacy can direct you on how to get rid of used needles and syringes. Raloxifene qSS9;a: 6h. Denosumab is a drug that may be recommended to reduce the risk of fractures. information is beneficial, we may combine your email and website usage information with Yes, Prolia (denosumab) does increase bone density. And if you've already had a fracture in your spine, your risk of having more than one broken bone in your spine is also increased. To help the patient relax, suggest they look in another direction if they want to. Hypocalcaemia is an identified risk of denosumab treatment, particularly in patients with severe renal impairment (creatinine clearance <30 mL per minute or receiving dialysis). Prolia is usually given once every 6 months. Denosumab slows the breakdown of bone and is effective when treatment is given twice yearly, but bone density can fall once treatment is stopped Give feedback about this page. They can give you extra painkillers or top-ups at these times. The active drug in Prolia is denosumab, which is a biologic medication. Its long-term effects are not yet known, but there are potentially serious side effects. If the skin is stretched flat, that only use a. Pancreatitis has been reported with Prolia. The drug is given by a healthcare professional as a subcutaneous injection. The next month got UTI and chill so much. Use it to try out great new products and services nationwide without paying full pricewine, food delivery, clothing and more. Important Safety Information Before you give an intramuscular injection, wash your hands with soap and warm water and sanitize the area with an alcohol swab to prevent infection. XGEVA is a prescription medicine used to prevent fracture, spinal cord compression, or the need for radiation or surgery to bone in patients with multiple myeloma and in patients with bone metastases from solid tumors. Denosumab injection comes as a solution (liquid) to be injected subcutaneously (under the skin) in your upper arm, upper thigh, or stomach area. What is cultural competency, and why is it crucial to healthcare? Denosumab 60 mg solution for injection (Prolia) is given once every 6 months to treat osteoporosis in postmenopausal women at increased risk of fractures. Pain, including joint pain, is a possible side effect of Prolia. Make sure you still have the correct dose in the syringe. The active ingredient in Prolia is denosumab. Supplements: Could a common dietary fiber trigger an allergy-like response? Usually, everyone who uses Prolia receives the same dosage, regardless of the condition that the drug is being used to treat. At your next appointment, use this conversation starter to find out, Phone support from trained nurses can help These are not all the possible side effects of XGEVA. The quicker the insertion, the less pain your patient will feel. In rare situations, your doctor may recommend that you self-inject doses of Prolia. Women on teriparatide or abaloparatide need to give themselves a daily injection. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Prolia (Denosumab) It is given when other medicines cannot be used or after other medicines did not work well. This site complies with the HONcode standard for trustworthy health information: verify here. Osteoporosis (See "Denosumab for osteoporosis".) This article has been viewed 570,971 times. Note: This document contains side effect information about denosumab. Besides learning about dosage, you may want other information about Prolia. if you are allergic to denosumab or any of the other ingredients of this medicine (listed in section 6). Keep Prolia and all medicines out of reach of children. You may opt-out of email communications at any time by clicking on However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Fosamax (alendronate) is a prescription drug thats used for bone conditions such as osteoporosis. When should you not give Prolia? Prednisone. A once-a-year injection is also far easier to schedule and stick to compared to having to remember a daily pill. Forteo (teriparatide) is a brand-name prescription medication approved to treat osteoporosis in adults. When should you not give Prolia? This article helped verify what I had previously learned and practiced during my 18-year career as a medic. When the patient is distracted, their muscle is more likely to be relaxed. Denosumab injection comes as a solution (liquid) to be injected subcutaneously (under the skin) in your upper arm, upper thigh, or stomach area. If the drug works well for you and youre not having bothersome side effects, youll likely use the drug over a long period. Took medicine, UTI gone but the chill stay. Denosumab injection comes as a solution (liquid) to be injected subcutaneously (under the skin) in your upper arm, upper thigh, or stomach area. This drug can be used: To help prevent or delay problems like fractures in men whose cancer has already spread to the bones. Serious side effects of Prolia. Comments will be used to improve web content and will not be responded to. Unusual thigh bone fracture has been reported. Denosumab (Brand name: Prolia ) Denosumab is an osteoporosis medication that can help to strengthen your bones and reduce your risk of breaking a bone. Denosumab belongs to a class of drugs called monoclonal antibodies. Severe jaw bone problems may happen when you take XGEVA. Some dosage forms listed on this page may not apply to the brand name Prolia. Include your email address to get a message when this question is answered. The recommended dose is one pre-filled syringe of 60 mg administered once every 6 months, as a single injection under the skin (subcutaneous). She received her Master of Science in Nursing (MSN) from the University of Tennessee in 2006. Comments will be used to improve web content and will not be responded to. Denosumab has been registered for the treatment of osteoporosis in Australia since 2010, and is subsidised by the Pharmaceutical Benefits Scheme for men and women over the age of 70 years with a T-score 2.5 or less, and for men and women with a minimal trauma fracture. Inform your oncologist of any dental work or if youre having tooth pain. Took medicine, UTI gone but the chill stay. Although no head-to-head trials have been published, a systematic review of nine RCTs (n = 4890) comparing the safety and efficacy of denosumab with bisphosphonate treatment for up to two years found no statistical difference between groups in terms of fracture risk or adverse events.9. Your doctor or nurse will give you this injection. For example, in the studies, people taking Prolia for up to 8 years didn't have significant side effects compared with people taking a placebo. Its a treatment for postmenopausal women who are unable to take certain bisphosphonates. Stay up-to-date with the latest information and resources on the COVID-19 vaccine rollout. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Mayo Clinic on Hearing and Balance - Mayo Clinic Press, NEW Mayo Clinic on Hearing and Balance, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. You are now leaving Prolia.com After your treatment with Prolia is stopped, or if you skip or delay taking a dose, your risk for breaking bones, including bones in your spine, is increased. Your doctor can give you drugs to help control some side effects. of Follow your doctors instructions about how long you should continue to receive Prolia injections. Do not administer into muscle or blood vessel. In these studies, everyone got the same dosage of Prolia, regardless of their age. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Osteoporosis (See "Denosumab for osteoporosis".) 410 0 obj <> endobj Take calcium and vitamin D as your doctor tells you to. of Health and Human Services, {"smallUrl":"https:\/\/www.wikihow.com\/images\/thumb\/b\/b7\/Give-an-Intramuscular-Injection-Step-3-Version-2.jpg\/v4-460px-Give-an-Intramuscular-Injection-Step-3-Version-2.jpg","bigUrl":"\/images\/thumb\/b\/b7\/Give-an-Intramuscular-Injection-Step-3-Version-2.jpg\/aid1384620-v4-728px-Give-an-Intramuscular-Injection-Step-3-Version-2.jpg","smallWidth":460,"smallHeight":345,"bigWidth":728,"bigHeight":546,"licensing":"