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This drug comes with several precautions. Evenity may also be used off-label for other conditions. Generics tend to cost less than brand-name drugs. Fosamax contains the active drug alendronate. [Ref], Very common (10% or more): Bone, muscle or joint pain (sometimes severe), Common (1% to 10%): Muscle cramp, joint swelling, Rare (less than 0.1%): Osteonecrosis of the jaw, atypical subtrochanteric and diaphyseal femoral fractures, Postmarketing reports: Myalgia, low-energy femoral shaft and subtrochanteric fractures[Ref], Rare (less than 0.1%): Rash with photosensitivity, severe skin reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis[Ref], Common (1% to 10%): Abdominal pain, dyspepsia, acid regurgitation, nausea, abdominal distension, constipation, diarrhea, flatulence, esophageal ulcer, gastritis, gastroesophageal reflux, Uncommon (0.1% to 1%): Gastric ulcer, esophagitis, esophageal erosions, melena, dysphagia, vomiting, Rare (less than 0.1%): Esophageal stricture, oropharyngeal ulceration, upper gastrointestinal PUB (perforation, ulcers, bleeding), Postmarketing reports: Localized osteonecrosis of the jaw, generally associated with tooth extraction and/or local infection with delayed healing[Ref], Common (1% to 10%): Vertigo, asthenia, peripheral edema, Uncommon (0.1% to 1%): Transient symptoms of myalgia, malaise and rarely, typically in association with initiation of treatment[Ref], Uncommon (0.1% to 1%): Eye inflammation (uveitis, scleritis, episcleritis)[Ref], Rare (less than 0.1%): Symptomatic hypocalcemia (often in association with predisposing conditions)[Ref], Rare (less than 0.1%): Urticaria, angioedema[Ref], Postmarketing reports: Acute asthma exacerbations[Ref]. Different hormonal therapies have different side effects. No, weight gain isnt a known side effect of Boniva. Boniva may cause several side effects. Follow all other instructions for taking Fosamax. You should always consult your doctor or other healthcare professional before taking any medication. Ask your doctor or nurse to explain the side effects before treatment. And if you have any risk factors for cardiovascular problems, talk with your doctor about whether Evenity is right for you. hormone therapy, which blocks male hormones to slow the growth of cancer cells, such as: immunotherapy, a type of treatment that helps the immune system fight cancer, such as: castration-sensitive* prostate cancer thats spread to other parts of the body, posterior reversible encephalopathy syndrome (PRES), a condition that causes swelling in your brain, castration sensitive* and high risk for getting worse, If your partner is taking Xofigo and you could become pregnant. Learn about side effects, alternatives, dosage, and more. However, injection site reactions are specific to the area where you received an injection. A generic drug is an exact copy of the active drug in a brand-name medication. The frequency of renal impairment adverse events suspected to be related to this drug was as follows: Multiple myeloma (3.2%), prostate cancer (3.1%), breast cancer (4.3%), lung and other solid tumors (3.2%). For this purpose, youll need to take the generic version of Fosamax, alendronate. Effectiveness in females with osteoporosis whod gone through menopause. The generic is considered to be as safe and effective as the original drug.). Talk with your doctor if you have questions about taking Boniva while pregnant or breastfeeding. But in animal studies, Evenity caused birth defects when given to pregnant animals. That said, Xofigo can have some side effects* in other parts of your body. These nutrients help your body build and maintain strong bones. Another treatment option for these conditions is the generic form of Fosamax, called alendronate. such as Prolia, may cause side effects. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. For this purpose, youll need to take the generic version of Fosamax, which is called alendronate. The second injection is given immediately after the first. Watts NB, Becker P "Alendronate increases spine and hip bone mineral density in women with postmenopausal osteoporosis who failed to respond to intermittent cyclical etidronate." Learn about the potential side effects of Aclasta (zoledronic acid). Youll get Evenity injections at your doctors office. Your doctor may recommend that you stop taking Fosamax and try a different medication to treat your condition. Off-label drug use means using a drug for a purpose other than what its been approved for by the FDA. In this study, BMD increased by 3.5% in females taking Prolia, compared with 2.6% in females taking alendronate. But keep in mind that you should take any supplements at least 30 minutes after taking Fosamax. If you drink alcohol, talk with your doctor about how much may be safe for you to drink while taking Evenity. BMD is a measurement of how strong your bones are. Note: In some cases, skin redness, swelling, and certain other symptoms can indicate an allergic reaction. This increases bone mineral density as well. Evenity is taken once per month for 12 months. Below are examples of these side effects. After these 30 minutes have passed, you should continue to avoid lying down until after you eat something. Peripheral edema may cause weight gain, but Fosamax itself doesnt directly cause weight gain as a side effect. (A class of medications is a group of drugs that work in a similar way.) Maconi G, Porro GB "Multiple ulcerative esophagitis caused by alendronate." What is cultural competency, and why is it crucial to healthcare? This decreased absorption can lead to a lack of calcium, which can weaken your bones. But the drug is only approved for use in certain females whove gone through menopause, which means that they can no longer get pregnant. JAMA 275 (1996): 1534, 13. They may recommend that you use one of the forms rather than the other. But your doctor will continue to monitor your bone strength and risk of fracture after you stop taking Fosamax. Xtandi contains enzalutamide. The actual price youll pay for either drug depends on your insurance plan, your location, and the pharmacy you use. This is the length of time it takes for the amount of radioactivity from your dose to decrease by half. Thats because the radiation it produces can damage your bone marrow. Or they may recommend that you stop treatment if youve been taking Fosamax for a certain amount of time. 2004-2022 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. For more information about the possible side effects of Xofigo, talk with your doctor or pharmacist. Both Evenity and Forteo are approved to treat: osteoporosis (in males or females) thats caused by taking certain, -1.0 to 1.0 means that you have normal BMD, -2.5 or lower means that you have osteoporosis, 0.5% of females who took Evenity had a new spinal fracture, compared with 1.8% of females who took a placebo. As you age, your body forms new bone more slowly. It can be helpful to sip on fluids throughout the day. Calcium and vitamin D are minerals that help your body build and maintain strong bones. (This was in comparison with people taking a placebo, which is a treatment with no active drug.). Although not all of these side effects may occur, if they do occur they may need medical attention. If you develop serious side effects while taking Boniva, call your doctor right away. If the T-score is -1.0 to -2.4, the diagnosis of osteopenia is made. After you take Fosamax, wait 30 minutes. Both of these forms are taken by mouth. Mbekeani JN, Slamovits TL, Schwartz BH, Sauer HL "Ocular inflammation associated with alendronate therapy." Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to zoledronic acid: intravenous powder for injection, intravenous solution. Some reports may have incomplete information. If prostate cancer spreads to your bones, the bone metastases can cause symptoms such as: * Use of the terms male or female within this article refers to a persons sex assigned at birth. Premarin side effects. compared with females who took a placebo, females who took Evenity had an average BMD that was: 5.2% higher in the femoral neck (the top of the thigh bone), 0.6% of females who took Evenity followed by denosumab, 2.5% of females who took a placebo followed by denosumab. Read on to learn more. If you have diarrhea with Xofigo, ask your doctor how to manage this. However, clinical studies were done to see if Fosamax could be used as a treatment in children with osteogenesis imperfecta. Graham, Malaty "Alendronate and naproxen are synergistic for development of gastric ulcers (Vol 161, pg 107, 1921)." Heres some detail on certain side effects this drug may or may not cause. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Mar 27, 2018. These symptoms may include: * This percentage varies because it was recorded from two separate clinical studies. hair loss or thinning of the hair; sensation of spinning; sensitivity of the eye to light; tearing; Prolia, hydrochlorothiazide, alendronate, estradiol, Premarin, calcium carbonate, raloxifene, Reclast, ibandronate, Zometa. The use of Evenity and Forteo in treating postmenopausal osteoporosis has been directly compared in clinical studies. What is cultural competency, and why is it crucial to healthcare? However, cancer, which this drug treats, often causes fatigue. Here, we look at how Evenity and Prolia are alike and different. Weight gain may occur during menopause. If you have Xofigo as an outpatient, its usually covered by Medicare Part B (medical insurance). To learn more about how to take Boniva, talk to your doctor or pharmacist or see this article. This review also found that Evenity may be more effective than Prolia for preventing hip fractures or other non-spinal fractures. However, be sure to take the dosage your doctor prescribes for you. 10. It also works to slow bone breakdown. In this study, Evenitys active drug was more effective than Forteos at increasing BMD in certain parts of the spine and hip. Prolia injections are given once every 6 months for as long as your doctor recommends. Bayer, the manufacturer of Xofigo, offers a program called Access Services that may provide ways to lower the cost of this drug. Red blood cells carry oxygen through the body. Its not known if its safe or effective to have more than six doses of Xofigo. You can also ask your pharmacist for information on how to dispose of your medication. And to help prevent hypocalcemia, Evenity should be taken with a daily calcium and vitamin D supplement. You may report them to the FDA. This side effect has also happened months after people took their first dose. Includes common and rare side effects information for consumers and healthcare professionals. In clinical trials, Fosamax was effective in treating Pagets disease of bone. However, a 2007 study directly compared alendronate and ibandronate tablets in treating osteoporosis in females whove gone through menopause. Kidney Int 64 (2003): 281-289. As with most drugs, some people can have an allergic reaction after taking Xofigo. Use of the term female in this article refers to sex assigned at birth. If youre interested in taking Evenity or Forteo, talk with your doctor about which drug might be the best option for you. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. And each monthly dose consists of two injections. If you need financial support to pay for Xofigo, or if you need help understanding your insurance coverage, help is available. And in females, alcohol may decrease estrogen. And only take a calcium and vitamin D supplement if your doctor recommends it. Fosamax, like other bisphosphonates, may irritate the esophagus and stomach. Graham DY, Malaty HM "Alendronate and naproxen are synergistic for development of gastric ulcers." * In males, alcohol may decrease testosterone. Zometa (zoledronic acid)." It belongs to a class of medications called bisphosphonates. The radioactivity of Xofigo decreases over time. The most common symptoms of an injection site reaction in these studies were: In addition, other possible symptoms can include swelling, hives, or itching at the site of injection. In this trial, females took either alendronate once a week by mouth or ibandronate once a month by mouth. Theres no known interaction between alcohol and Xofigo. They can give you tips on how to deal with any side effects that may be bothersome. The amazing story of hepatitis C, from discovery to cure. Osteoclasts can also break down bone to release calcium into your bloodstream. For these uses, both Evenity and Forteo are approved for use in certain people who: Evenity and Forteo are both given as a subcutaneous injection (an injection under the skin). The following information is provided for clinicians and other healthcare professionals. To help make sure that you dont miss a dose, try setting a reminder on your phone. You should take Fosamax when your stomach is empty, first thing in the morning. The oral solution is only available as the generic form of Fosamax, called alendronate. Mild side effects that have been reported with Boniva include: These side effects may be temporary, lasting a few days to weeks. Call your doctor right away if you have serious side effects. These are just a few of the more common side effects reported by people who took Boniva in clinical studies: Mild side effects can occur while taking Boniva. McClung M, Clemmesen B, Daifortis A, et al. If you have problems with your esophagus, such as difficulty swallowing, its important to tell your doctor before taking Boniva. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. (Keep in mind that Fosamax and alendronate should be taken first thing in the morning.) * Sex and gender exist on spectrums. Fosamax and Prolia have some different FDA-approved uses, but they are both used to: The use of Fosamax and Prolia in treating these kinds of osteoporosis hasnt been directly compared in clinical studies. "Product Information. Learn about the potential side effects of hydrochlorothiazide. This is because your body may not be able to get rid of the medication properly. Xofigo is not FDA-approved to treat breast cancer. However, the Food and Drug Administration (FDA) has been reviewing clinical studies to see if theres a link between medications such as Fosamax and cancer of the esophagus. Insomnia, for example, is not technically a loss of sleep, but the result of a state of continuous hyperarousal, and stress is a major cause. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Serious side effects and their symptoms can include: * For more information about this side effect, see Side effect details below. Its not currently available in biosimilar form. The volume of distribution at steady state is at least 28 liters. Talk with your doctor about getting your vaccines up to date before you start treatment with Xofigo. This genetic bone condition causes very weak, fragile bones. Before approving coverage for Xofigo, your insurance company may require you to get prior authorization. It could be, if prescribed by a doctor for this use. For more information about taking other medications with Fosamax, see the Fosamax interactions section below. Xofigo can cause mild or serious side effects. However, this side effect has been reported, though rarely, since the drug came onto the market. Your doctor can also help create a weight management plan thats healthy for you. Doing these things can increase your risk of an ulcer in your esophagus. (Alendronate is the active drug in Fosamax. Although Xofigo is a form of radiation therapy, this drug only gives off a weak form of radiation. Learn about side effects, warnings, and more. So, as both females and males age, their risk of osteoporosis increases. These medications can cause some similar side effects but some different ones as well. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Supplements: Could a common dietary fiber trigger an allergy-like response? Some conditions, such as celiac disease and lactose intolerance, can prevent your body from absorbing nutrients, such as calcium. Fosamax costs significantly less than Prolia. 3. In males,* the bioavailability of alendronate taken in the morning, 2 hours before breakfast, is 0.59%. Nussbaum SR, Warrell RP Jr, Rude R, Glusman J, Bilezikian JP, Stewart AF, Stepanavage M, Sacco JF, Averbuch SD, Gertz BJ "Dose-response study of alendronate sodium for the treatment of cancer- associated hypercalcemia." have tried and stopped other osteoporosis treatments because they either: caused side effects that were bothersome or severe, pins and needles, tingling, or burning sensations, injection site reactions, such as pain or redness, numbness or tingling in your fingers or toes or around your mouth, numbness or a feeling of heaviness in your jaw, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, chest pain or pressure, which may spread to your arm or jaw, numbness or weakness on one side of your face or body, 8.1% to 13.1% of females who took Evenity*, 5.2% to 6.6% of females who took Evenity*, 1.7% to 2.4% of females who took Evenity*. The actual price youll pay for either drug depends on your insurance plan, your location, and the pharmacy you use. Along with its needed effects, alendronate (the active ingredient contained in Fosamax) may cause some unwanted effects. Some may be a better fit for you than others. If you have low levels of platelets, this can lead to easy bruising or bleeding. You can use the study as a second opinion to make health care decisions. Before taking Xofigo, talk with your doctor about your health history. These lists contain up to 10 of the most common mild side effects that can occur with each drug, as well as mild side effects that both drugs may share. Use of the term female and males in this article refers to sex assigned at birth. This is because the safety and effectiveness of Boniva when taken for longer than 3 years isnt known. Xofigo is FDA-approved to treat prostate cancer that has spread to your bones. Some cases have been severe enough to warrant hospitalization. This imbalance can lead to a loss of bone mineral density (BMD). The following information describes dosages that are commonly used or recommended. Continue reading for a comprehensive list of adverse effects. Boniva can also decrease calcium levels as a side effect. And if you have osteoporosis, drinking alcohol may worsen the condition. If you miss an appointment to get your Evenity injections, call your doctors office right away to reschedule your appointment. Serious side effects and their symptoms can include: * Evenity has a boxed warning for these side effects. joint pain or swollen joints. Bisphosphonates decrease the rate that bone is destroyed, which slows down the rate of bone loss. However, some females had peripheral edema while taking Evenity in clinical trials. Fever is the most common adverse effect associated with zoledronic acid (the active ingredient contained in Zometa) infusion. Note: If youre taking alendronate, the generic form of Fosamax, you can also follow the instructions below for how to take Fosamax. This causes damage to your bones, including in your jaws and teeth. Your doctor or nurse will explain this to you. You should take Fosamax according to your doctors or healthcare professionals instructions. Read on to learn about potential common, mild, and serious side effects. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. But its worth noting that these studies didnt compare how effective the drugs were in preventing fractures. This increases the strength of your bones, both inside and out. Learn about side effects, dosage, alternatives, and more.

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